KMID : 0670820110160010016
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Korean Journal of Medical Mycology 2011 Volume.16 No. 1 p.16 ~ p.23
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In vitro Antifungal Susceptibility Testing of Clinically-isolated Trichophyton Species to Luliconazole
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Hwang Young-Ji
Lee Yang-Won Choe Yong-Beom Ahn Kyu-Joong
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Abstract
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Background: Luliconazole (LLCZ) is an imidazole antifungal agent widely used in Japan for treatment of tinea, cutaneous candidiasis, and pityriaisis versicolor, etc. Theoretically, its potent antifungal activity should make it a viable option for various conditions of dermatophytoses, but there has been no studies to support the notion thus far.
Objective: This prompted the authors to investigate the distribution of minimum inhibitory concentration (MIC) of luliconazole by carrying out in vitro antifungal susceptibility test on Trichophyton (T.) species clinically isolated from Korean subjects with tinea pedis.
Methods: In vitro antifungal susceptibility test, with broth macrodilution method of luliconazole and terbinafine hydrochloride (TBF) as reference drug on two clinically isolated Trichophton species (22 strains of T. rubrum, 5 of T. mentagrophytes), was carried out.
Results: The range of MIC for LLCZ on the total of 27 strains was 0.0110~0.0140 ¥ìg/mL (geometric mean: 0.0027 ¥ìg/mL), and the range for TBF was 0.0120~0.0250 ¥ìg/mL (geometric mean: 0.0042 ¥ìg/mL). Additionally, the geometric mean for MIC of LLCZ on T. mentagrophytes was 0.0125 ¥ìg/mL, and on T. rubrum, it was 0.0019 ¥ìg/mL. No strain showed resistance in vitro.
Conclusions: The authors hence demonstrated that antifungal activity of LLCZ in vitro against Trichophyton species clinically isolated from Korean subjects is quite superior. These findings emphasize the usefulness of LLCZ, a promising new imidazole, for the topical management of dermatophytoses.
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KEYWORD
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Luliconazole, Trichophyton, Minimum inhibitory concentration
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